|Year : 2020 | Volume
| Issue : 4 | Page : 234-235
‘COVID-19: nephrologists in the battle crosswords’
Moatasem Elsayed, Hussein Sheashaa
Urology and Nephrology Center, Mansoura University, Mansoura, Egypt
|Date of Submission||23-Aug-2020|
|Date of Acceptance||26-Aug-2020|
|Date of Web Publication||16-Oct-2020|
Dr. Hussein Sheashaa
Professor of Nephrology and Internal Medicine, Urology and Nephrology Center, Mansoura University, Egyptian Society of Nephrology and Renal Transplantation, CME and Distance Learning Chapter Chair, Urology and Nephrology Center, El_Gomhoria Street, Mansoura, PO Box: 35516
Source of Support: None, Conflict of Interest: None
Coronaviruses are important human and animal pathogens. At the end of 2019, a novel coronavirus (ie, SARS-CoV-2) was identified as the cause of a cluster of pneumonia cases in Wuhan, a city in the Hubei Province of China. By 2020, it rapidly spread until it became a pandemic that has spread throughout the world. SARS-CoV-2 disease (COVID-19) mainly manifests as a respiratory infection ranging from those of a mild upper respiratory symptom to severe pneumonia, acute respiratory distress syndrome, and death. COVID-19 Severely affects patients with pre-existing comorbidities, such as patients with various types of kidney disease, hypertension, diabetes and elderly. All medical professionals, including nephrology clinicians, are tasked with rapidly adjusting their practice to withhold the spread of the virus, while providing the usual medical care to their patients. In this crosswords we hope to provide a basic and essential information in a simple manner describing the relationship between COVID-19 infection and kidney diseases.
Keywords: AKI, ATN, COVID 19, CRRT, proteinuria, RRT
|How to cite this article:|
Elsayed M, Sheashaa H. ‘COVID-19: nephrologists in the battle crosswords’. J Egypt Soc Nephrol Transplant 2020;20:234-5
Authors’ contributions: Hussein Sheashaa and Moatasem Elsayed in collaboration performed data collection, wrote the questions and their answers. [Figure 1] Hussein Sheashaa revised and edited the manuscript. The requirements for authorship as stated earlier in this document have been met, and that each author believes that this manuscript represents honest work.
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- On its surface ACE II is mainly expressed in human kidney.
- The preferred HD modality among critically ill patients with AKI induced by COVID-19.
- Not preferred as a HD anticoagulant in hepatic patients with COVID-19 infection.
- An antibiotic when combined with hydroxychloroquine increases the risk of QT prolongation and cardiotoxicity.
- A receptor for SARS-CoV-2.
- An important risk factor for mortality in COVID-19.
- The preferred type of fluid for resuscitation in adult and pediatric patients with septic shock.
- In vitro data proved that it may be speculated to be the preferred CNI during COVID-19 pandemic.
- An immunosuppressive drug which should be stopped as it may cause pneumonitis which could be misdiagnosis as suspicious for CoVID-19.
- An oral hypoglycemic drug which should be discontinued in critically ill patients because it increases the risk of GIT side effects and risk of aspiration.
- An organ in which ACE I receptors are much more expressed than ACE II receptors.
- An organ in which ACE I and ACE II receptors are almost equally expressed.
- You don’t have to discontinue it as an anti-hypertensive drug in COVID-19 patients.
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- One of the commonest histopathological finding in COVID-19 inducing AKI.
- A histopathological result for endothelial damage caused by COVID-19.
- One of the most common presentation of kidney disease with COVID-19.
- The minimum required dialysis membrane to be used for COVID-19 patients.
- The preferred HD membrane for COVID-19 patients which can be used in high convection dialysis.
- The primary mean of (SARS-CoV-2) transmission.
- A Laboratory features associated with severe COVID-19.
- It binds to ACE II receptor allowing the virus entry into the human cells.
- An immunosuppressive drug which is preferred to be stopped at all or replaced by steroid (in steroid free regimen) for kidney transplant patients infected with COVID-19.
- An immunosuppressive drug which should be stopped or carefully monitored when using anti-retroviral drug (ritonavir) for COVID-19 treatment.
- The best antidiabetic drug in critically ill COVID-19 diabetic patients.
- An oral hypoglycemic drug which is generally well tolerated and carries a theoretical benefit by blocking the functional receptor of COVID-19.
- An oral hypoglycemic drug which should be discontinued in critically ill patients because it increases the risk of dehydration and euglycemic ketoacidosis.
- An organ in which ACE II receptors are much more expressed than ACE I receptors.
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Conflicts of interest
There are no conflicts of interest.