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REVIEW ARTICLE
Year : 2021  |  Volume : 21  |  Issue : 3  |  Page : 115-123

Induction agents and their role in low-immunological-risk kidney transplant recipients: A Review


1 Department of Nephrology and Kidney Transplantation, University of Toronto, Toronto, Canada
2 Faculty of Health and Science, University of Liverpool, Institute of Learning and Teaching, School of Medicine, Liverpool; Department of Transplantation Surgery, Royal Liverpool University Hospital, Liverpool, United Kingdom
3 Faculty of Health and Science, University of Liverpool, Institute of Learning and Teaching, School of Medicine, Liverpool; Department of Transplantation Surgery, Sheffield Teaching Hospital, Sheffield, United Kingdom

Correspondence Address:
Dr. Ahmed M Halawa
MEd (Higher Education), FRCS, FRCS (Gen), Department of Transplantation Surgery, Sheffield Teaching Hospital, Sheffield S5 7 AU
United Kingdom
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jesnt.jesnt_12_21

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Induction agents are widely used at the time of kidney transplantation to decrease the risk of rejection. While there is a strong immunological rationale supporting the use of induction immunosuppression, the clinical evidence demonstrating benefit in low-immunological-risk recipients in addition to current effective maintenance immunosuppression is less robust, especially in terms of improvement in long-term graft survival. This review aims to shed light on the immunological basis of use of induction immunosuppression, available options of induction agents and the current evidence and recommendation for their use in low-immunological-risk kidney transplant recipients.


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