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CASE REPORT
Year : 2021  |  Volume : 21  |  Issue : 3  |  Page : 144-147

Successful kidney transplantation of a patient with thalassemia major: case report and review of literature


1 Department of Internal Medicine and Nephrology, Hamed Alessa Organ Transplant Center, Kuwait
2 Department of Internal Medicine and Nephrology, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt
3 MRCP-E Internal Medicine and Nephrology, Hamed Alessa Organ Transplant Center, Kuwait
4 MRCP-I Internal Medicine and Nephrology, Hamed Alessa Organ Transplant Center, Kuwait

Correspondence Address:
Dr. Osama Gheith
Internal Medicine and Nephrology, Consultant Nephrologist, Urology and Nephrology Center, Mansoura University; Working in Hamed Alessa Organ Transplant Center, Kuwait; Hamed Al-Essa Organ Transplant Center, Ministry of Health, Ibn Sina Hospital, P.O. Box 25427, Safat (13115), Kuwait
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jesnt.jesnt_5_21

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Thalassemia minor has a good prognosis, whereas thalassemia major (TM) is a severe disease, and the long-term prognosis depends on the treatment adherence to transfusion and iron chelation therapies. To our knowledge, there are no reported thalassemia cases that underwent kidney transplant. We aimed to highlight a successful kidney transplant in a patient with TM with stable graft function after 16 months of follow-up. In our case, repeated blood transfusions were inevitably associated with iron overload despite iron chelating agents. Moreover, she developed anti-HLA antibodies, but fortunately, there were no donor-specific antibodies, which facilitated the procedure of renal transplant that was performed on 17/3/2019. After 6 weeks of transplant, she started follow-up in the clinic and resumed iron chelation using deferasirox along with much less frequent blood transfusion. After more than 20 months of follow-up, she is enjoying stable graft function, hemoglobin around 9.2 g/dl, and with occasional trace proteinuria. This is a case report showing a β-TM case can undergo renal transplant with no contraindications under special circumstances, and it is the first case in the literature.


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